
Luigi's Girls
Luigi wants Claude to pick up one of his working girls from the clinic and bring her back to his club.
Once on foot, the game will instruct us to get a vehicle. The Kuruma from the previous mission will still be parked out front, so you can take that if you want, otherwise steal anything that drives past.
You'll then be told to pick up Misty who is marked by a green blip on the radar. The GPS will guide you to the hospital so make your way there. On the way, you'll be told that you can view a map of the city in the pause menu, and that you can change the radio station by pressing the D-Pad Right button, or viewing the radio wheel by holding down the L1 button.
When you arrive at the hospital, you'll be told to stop the vehicle next to Misty so she can get in. Make sure you don't run her over!
Once she's inside, she'll introduce herself, then you'll need to follow the route back to Luigi's club. The game will continue with the instructions, explaining you can rotate and adjust the camera by moving the Right Analog stick and change the camera mode by pressing the Touch Pad button.
Park up in the blue circle when you reach Luigi's club.
Mission Passed!
After the mission you'll be told you can visit Luigi for a new mission.
The game will also drop a hint that stealing a taxi could be a good way to make some extra money.
- Reward: $1,500
- Mission Unlocked: Don't Spank Ma Bitch Up
- You're now free to explore Portland.
- You can save your game at the safehouse, marked on the radar with a pink house icon.
- There are numerous side missions and objectives you can attempt around Portland, including:
- 33 Hidden Packages to collect (although 2 of them are technically inaccessible at this point in time).
- 6 Rampages to complete.
- 8 Unique Stunt Jumps to complete.
- The 'Diablo Destruction' and 'Mafia Massacre' RC Car Destruction challenges can be attempted.
- The 'Patriot Playground' off-road checkpoint challenge can be attempted.
- Taxi Driver (100 Fares), Paramedic (Level 12), Vigilante (20 Kills on Portland) and Firefighter (20 Fires Extinguished on Portland) vehicle sub-missions can be attempted, most of which unlock useful bonuses that will help with gameplay.
- You can begin delivering vehicles to the Import/Export Garage and Emergency Vehicle crane at Portland Harbor.
Because the Callahan Bridge was destroyed by the bomb, and the road tunnel is under construction, there's no way to reach the other islands. Access will be unlocked as you continue through the story missions. There is, however, an exploit which allows you to reach both of the other islands at this point of the game, meaning you can complete a huge amount of the side content - with 53% overall completion - before playing another story mission...

If you reach other islands early with the tunnel exploit, you can also attempt the following side tasks.
Portland
- You can collect the 2 additional Hidden Packages in Portland. One by taking a boat from the docks on Staunton Island, the other by following the subway tunnel.
- You can fly the Dodo from Shoreside Vale to deliver it to the Import/Export garage early. Doing this makes it possible to deliver all of the Import/Export vehicles to the garage.
Staunton Island
- 36 Hidden Packages to collect.
- 7 Rampages to complete.
- 4 Unique Stunt Jumps to complete.
- The 'Casino Calamity' RC Car Destruction challenge can be attempted.
- The 'Multistory Mayhem' and 'A Ride In The Park' off-road checkpoint challenges can be attempted.
- Vigilante (20 Kills on Staunton) and Firefighter (20 Fires Extinguished on Staunton) vehicle sub-missions can be attempted.
- You can save your game at the Staunton Island safehouse and store 2 vehicles in the double garage.
Shoreside Vale
- 31 Hidden Packages to collect - 1 of which will require flying the Dodo onto the top of the Shoreside Lift Bridge.
- 7 Rampages to complete.
- 8 Unique Stunt Jumps to complete.
- The 'Rumpo Rampage' RC Car Destruction challenge can be attempted.
- The 'Gripped!' off-road checkpoint challenge can be attempted.
- Vigilante (20 Kills on Shoreside) and Firefighter (20 Fires Extinguished on Shoreside) vehicle sub-missions can be attempted.
- You can save your game at the Shoreside Vale safehouse and store 3 vehicles in the triple garage.
- You can begin delivering vehicles to the Import/Export Garage in Pike Creek. It's possible to deliver every vehicle except the BF Injection at this point.