Sal points a 9mm Pistol at Toni, thinking he's been saying bad things about him. He kinda comes to his senses - he blames the Mayor for the shit he has to take as a Mafia Don. He wants to get to Staunton Island to figure out his next move.
Head to the Ferry Terminal at Harwood, where you will gain a 3-star wanted level. Drive to the Callahan Bridge, which is suitable enough to drive over. You now have to drive to Newport to your new safehouse.
You have unlocked Staunton Island. You can explore the island and get a new feel to it if you want.