Introduction8-Ball thinks he can find a lead to who murdered Vinnie by getting you to pick up some girls and drop them off at their Johns. You've got 4 minutes to pick up 3 girls and deliver them separately to their specified locations. You'll need to be in a vehicle to start this mission.
Special DeliveryFrom the start of the mission, my preferred choice is to head South in order to pick up the girl from there first. She'll want to be taken to the North West of Portland.
Next, head South to the next girl, who will want to be taken even further South. Nice and simple.
Then finally head back North to the one remaining girl up there. She'll want to be taken South again.
You should be able to pass this mission with around 2 minutes remaining so it's nothing difficult.